Description

((6-Methoxy-5,6,7,8-Tetrahydronaphthalen-2-Yl)Ethynyl)Trimethylsilane is a high-purity, advanced pharmaceutical intermediate characterized by its unique naphthalene-based structure with a protected ethynyl group. This compound is critical for enabling complex synthetic routes in medicinal chemistry, offering a versatile building block for constructing novel molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Organic Synthesis Building Block: Used in cross-coupling reactions (e.g., Sonogashira) and other catalytic transformations to introduce functionalized aromatic systems.
• Material Science Research: Serves as a precursor for developing organic semiconductors or liquid crystalline materials due to its rigid, conjugated backbone.
• Agrochemical Development: Employed in the research phase for creating novel crop protection agents with enhanced efficacy.
• Academic & R&D Laboratories: Used in methodological studies and for exploring new reaction pathways in synthetic organic chemistry.

Basic Information

Product Name	((6-Methoxy-5,6,7,8-Tetrahydronaphthalen-2-Yl)Ethynyl)Trimethylsilane
CAS No.	937594-15-5
Molecular Formula	C₁₈H₂₄OSi
Molecular Weight	284.47 g/mol
Synonyms	2-((Trimethylsilyl)ethynyl)-6-methoxy-1,2,3,4-tetrahydronaphthalene; 6-Methoxy-2-((trimethylsilyl)ethynyl)-1,2,3,4-tetrahydronaphthalene; ((6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)ethynyl)trimethylsilane; TMS-protected 6-Methoxytetralin acetylene derivative; (6-Methoxy-3,4-dihydronaphthalen-2(1H)-yl)ethynyltrimethylsilane
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Each batch is analyzed using advanced chromatographic and spectroscopic techniques to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.