Description

Ethanone, 1-[3,4-Dihydro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2(1H)-Isoquinolinyl]- is a specialized boronic ester derivative of a tetrahydroisoquinoline scaffold, serving as a critical advanced pharmaceutical intermediate (API) and building block in modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical R&D, agrochemical discovery, and material science, where precise molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient and selective formation of biaryl and other C-C bonds in complex molecule synthesis.
• Agrochemical Synthesis: Used in the research and development of new active ingredients for crop protection products.
• Material Science Research: Serves as a precursor for creating organic electronic materials, ligands for catalysts, and functional polymers.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Industrial R&D: A versatile tool for methodological development and exploration of new chemical spaces in laboratory settings.

Basic Information

Item	Details
Product Name	Ethanone, 1-[3,4-Dihydro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2(1H)-Isoquinolinyl]-
CAS No.	937591-82-7
Molecular Formula	C₁₇H₂₂BNO₃
Molecular Weight	299.18 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2(1H)-isoquinolin-1-yl ethanone; 1-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-isoquinolin-1-yl]ethanone; 5-Pinacolboryl-1-acetyl-1,2,3,4-tetrahydroisoquinoline; 1-Acetyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline; Boronic acid, B-[1-(acetyl)-1,2,3,4-tetrahydro-5-isoquinolinyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our Ethanone, 1-[3,4-Dihydro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2(1H)-Isoquinolinyl]- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.