Description

2-[(tert-Butoxy)Carbonyl]-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylic Acid (Wx142476) is a high-purity, protected amino acid derivative belonging to the tetrahydroisoquinoline class, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile chiral intermediate for constructing complex pharmaceutical molecules, particularly in the development of active pharmaceutical ingredients (APIs) and bioactive compounds. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for peptide mimetics and heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Peptidomimetic Scaffold: Used to construct constrained peptide analogs and protease inhibitors by incorporating the rigid tetrahydroisoquinoline core.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce chiral centers into complex molecular architectures.
• Medicinal Chemistry Research: Serves as a versatile building block in lead optimization and structure-activity relationship (SAR) studies.
• Agrochemical Development: Potential intermediate for creating novel herbicides or plant growth regulators with specific chiral activity.
• Chemical Biology Probes: Used to develop tool compounds and labeled ligands for studying biological targets and pathways.

Basic Information

Item	Details
Product Name	2-[(tert-Butoxy)Carbonyl]-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylic Acid (Wx142476)
CAS No.	936829-00-4
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	1,2,3,4-Tetrahydroisoquinoline-4-carboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-; 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid; Boc-Tic-OH; (4S)-2-[(tert-Butoxy)carbonyl]-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid; (R)-2-((tert-Butoxycarbonyl)amino)-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid; WX-142476; Wx142476
EINECS	Contact for details

Quality Control

Our 2-[(tert-Butoxy)Carbonyl]-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under dry conditions to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.