Description

1H-Indole-6-Carboxylic Acid, 3-[(1R,2S)-2-Hydroxycyclohexyl]-, Methyl Ester, Rel- is a high-purity, stereochemically defined chiral indole derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for the development of novel active compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to introduce the indole-carboxylate moiety with defined stereochemistry.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for lead optimization.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic & Institutional Research: Used in universities and research institutes for studies in synthetic methodology and heterocyclic chemistry.

Basic Information

Item	Detail
Product Name	1H-Indole-6-Carboxylic Acid, 3-[(1R,2S)-2-Hydroxycyclohexyl]-, Methyl Ester, Rel-
CAS No.	936711-50-1
Molecular Formula	C16H19NO3
Molecular Weight	273.33 g/mol
Synonyms	rel-(1R,2S)-2-Hydroxycyclohexyl 6-(Methoxycarbonyl)-1H-indole-3-carboxylate; Methyl 3-[(1R,2S)-2-Hydroxycyclohexyl]-1H-indole-6-carboxylate; 3-[(1R,2S)-2-Hydroxycyclohexyl]-1H-indole-6-carboxylic Acid Methyl Ester; (rel)-(1R,2S)-Methyl 3-(2-hydroxycyclohexyl)-1H-indole-6-carboxylate; 936711-50-1; Chiral Indole Ester Derivative
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and enantiomeric purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.