Description

1-(Isoquinoline-5-Sulfonyl)-Piperidin-4-Ylamine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate and research chemical. This compound is critical for medicinal chemistry research, particularly in the development of novel enzyme inhibitors and targeted therapeutics. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates targeting specific biological pathways.
• Biochemical Research: Used as a selective chemical probe or inhibitor in enzymatic and cellular assays to study protein function and signaling mechanisms.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Protease Inhibitor Development: The sulfonamide and amine functionalities make it a relevant precursor for compounds designed to interact with protease active sites.
• Kinase Inhibitor Research: Applied in the discovery and development of kinase inhibitors due to the structural motifs common in this class of therapeutics.
• Chemical Library Synthesis: Used to generate diverse compound libraries for high-throughput screening (HTS) against novel biological targets.

Basic Information

Product Name	1-(Isoquinoline-5-Sulfonyl)-Piperidin-4-Ylamine Dihydrochloride
CAS No.	936250-33-8
Molecular Formula	C14H20Cl2N4O2S
Molecular Weight	379.31 g/mol
Synonyms	1-(Isoquinolin-5-ylsulfonyl)piperidin-4-amine dihydrochloride; 4-Amino-1-(isoquinoline-5-sulfonyl)piperidine dihydrochloride; 1-(5-Isoquinolinesulfonyl)-4-piperidinamine dihydrochloride; Piperidin-4-amine, 1-(5-isoquinolinesulfonyl)-, dihydrochloride; 936250-33-8; 1-(Isoquinoline-5-sulfonyl)piperidin-4-amine 2HCl
EINECS	Contact for details

Quality Control

Our 1-(Isoquinoline-5-Sulfonyl)-Piperidin-4-Ylamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.