Description

5-Bromo-1-(Difluoromethoxy)-2,3-Difluoro-Benzene is a high-purity, multi-functional fluorinated aromatic building block of significant commercial interest. Its unique structure, featuring bromine and difluoromethoxy substituents on a difluorobenzene core, makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs). This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic components in electronic display materials, leveraging its stability and electronic properties.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart desired characteristics such as chemical resistance, thermal stability, or specific optical properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira) for constructing complex biaryl systems.
• Organic Synthesis Building Block: Employed in academic and industrial research for the synthesis of complex fluorinated organic compounds for various high-value applications.

Basic Information

Product Name	5-Bromo-1-(Difluoromethoxy)-2,3-Difluoro-Benzene
CAS No.	936249-95-5
Molecular Formula	C7H3BrF4O
Molecular Weight	274.99 g/mol
Synonyms	2,3-Difluoro-5-bromo-1-(difluoromethoxy)benzene; 1-Bromo-3,4-difluoro-5-(difluoromethoxy)benzene; 5-Bromo-2,3-difluoro-1-(difluoromethoxy)benzene; Benzene, 5-bromo-1-(difluoromethoxy)-2,3-difluoro-; 936249-95-5; 5-Bromo-1-(difluoromethoxy)-2,3-difluorobenzene
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-(Difluoromethoxy)-2,3-Difluoro-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.