Description

4-Methoxytriphenylmethyl Chloride is a specialized protecting group reagent widely used in organic synthesis, particularly in oligonucleotide and peptide chemistry. Its core value lies in its selective reactivity, enabling the protection of hydroxyl groups under mild conditions, which is crucial for constructing complex biomolecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and life science industries who require high-purity intermediates for advanced synthetic applications.

Application

• Oligonucleotide Synthesis: Primarily used as a protecting group reagent for the 5'-hydroxyl group in the solid-phase synthesis of DNA and RNA fragments.
• Peptide Chemistry: Employed for the selective protection of hydroxyl-containing amino acid side chains (e.g., serine, threonine, tyrosine) during peptide synthesis.
• Carbohydrate Chemistry: Useful in the synthesis of complex sugars and glycoconjugates for protecting specific hydroxyl functionalities.
• Pharmaceutical Intermediates: Serves as a key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.
• Agrochemical Research: Applied in the development and synthesis of novel herbicides, pesticides, and plant growth regulators.
• Material Science: Can be utilized in the surface modification of polymers and the creation of functionalized materials.

Basic Information

Product Name	4-Methoxytriphenylmethyl Chloride
CAS No.	14470-28-1
Molecular Formula	C20H17ClO
Molecular Weight	308.80 g/mol
Synonyms	MMTr-Cl; 4-Monomethoxytrityl Chloride; (4-Methoxyphenyl)diphenylmethyl Chloride; p-Methoxytrityl Chloride; 4-Methoxytrityl Chloride; Chloro(4-methoxyphenyl)diphenylmethane; 1-Chloro-1-(4-methoxyphenyl)-1,1-diphenylmethane
EINECS	Contact for details

Quality Control

Our 4-Methoxytriphenylmethyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	108 - 112 °C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.