Description

(R)-Isoquinoline-5-Sulfonic Acid Pyrrolidin-3-Ylamide Dihydrochloride is a high-purity, chiral organic intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of potential drug candidates, especially in neuroscience and oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new small-molecule therapeutics.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the design of enzyme inhibitors due to its sulfonamide and amide functionalities.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and protein functions.
• Asymmetric Synthesis: Employed as a chiral auxiliary or reagent in stereoselective synthetic routes to access enantiomerically pure compounds.
• Fine Chemical Synthesis: Acts as a specialized intermediate for custom synthesis and contract manufacturing of complex organic molecules.

Basic Information

Product Name	(R)-Isoquinoline-5-Sulfonic Acid Pyrrolidin-3-Ylamide Dihydrochloride
CAS No.	936233-14-6
Molecular Formula	C₁₃H₁₉Cl₂N₃O₂S
Molecular Weight	352.28 g/mol
Synonyms	(R)-5-(Pyrrolidin-3-ylcarbamoyl)isoquinoline-8-sulfonic acid dihydrochloride; (R)-Isoquinoline-5-sulfonic acid, 1,2,3,4-tetrahydro-8-[[(3R)-3-pyrrolidinyl]amino]carbonyl]-, dihydrochloride; (R)-8-[(3-Pyrrolidinylamino)carbonyl]-1,2,3,4-tetrahydro-5-isoquinolinesulfonic acid dihydrochloride; (R)-TIQ-A Dihydrochloride; Pyrrolidin-3-yl-[(R)-1,2,3,4-tetrahydroisoquinolin-5-yl]sulfonylamide dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Isoquinoline-5-Sulfonic Acid Pyrrolidin-3-Ylamide Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided to guarantee identity, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.