Description

(R)-1-(Isoquinoline-5-Sulfonyl)-Pyrrolidin-3-Ylamine Dihydrochloride is a high-purity, chiral chemical building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel therapeutic agents, particularly those targeting specific enzyme pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the discovery of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore novel chemical space.
• Process Chemistry Development: Serves as a starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Biochemical Tool Compound: Potential use in biochemical assays as a selective inhibitor or probe to study specific biological mechanisms and enzyme functions.
• Asymmetric Synthesis: Utilized in the preparation of enantiomerically pure compounds due to its defined (R)-configuration at the chiral center.
• Custom Synthesis & Contract Manufacturing: A building block for custom synthesis services catering to the specific needs of biotechnology and pharmaceutical partners.

Basic Information

Product Name	(R)-1-(Isoquinoline-5-Sulfonyl)-Pyrrolidin-3-Ylamine Dihydrochloride
CAS No.	936233-13-5
Molecular Formula	C₁₃H₁₉Cl₂N₃O₂S
Molecular Weight	352.28 g/mol
Synonyms	(R)-1-(Isoquinolin-5-ylsulfonyl)pyrrolidin-3-amine dihydrochloride; (3R)-1-(Isoquinoline-5-sulfonyl)-3-pyrrolidinamine dihydrochloride; (R)-3-Amino-1-(isoquinoline-5-sulfonyl)pyrrolidine dihydrochloride; Pyrrolidin-3-amine, 1-(5-isoquinolinylsulfonyl)-, (3R)-, dihydrochloride; UNII-9V3J8Q6Y0R; 9V3J8Q6Y0R; (R)-1-(Isoquinoline-5-sulfonyl)pyrrolidin-3-amine 2HCl
EINECS	Contact for details

Quality Control

Our (R)-1-(Isoquinoline-5-Sulfonyl)-Pyrrolidin-3-Ylamine Dihydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical data, including chiral purity verification by HPLC. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.