Description

(S)-1-(Isoquinoline-5-Sulfonyl)-Pyrrolidin-3-Ylamine Dihydrochloride is a high-purity, chiral chemical building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for synthesizing novel therapeutic agents, particularly those targeting specific enzyme pathways. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in drug discovery programs. The dihydrochloride salt form enhances stability and solubility, facilitating its use in complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, especially for central nervous system (CNS) and oncology targets.
• Protease Inhibitor Research: Used in the development of inhibitors for various protease enzymes, leveraging the isoquinoline-sulfonyl pharmacophore.
• Chemical Biology Probes: Serves as a scaffold for creating activity-based probes to study enzyme function and mechanism in biological systems.
• Library Synthesis for High-Throughput Screening (HTS): Employed in the construction of diverse compound libraries to identify new lead molecules.
• Asymmetric Synthesis: Utilized in chiral pool synthesis due to its defined (S)-configuration at the pyrrolidine amine center.
• Academic Research: Used in university and institutional labs for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	(S)-1-(Isoquinoline-5-Sulfonyl)-Pyrrolidin-3-Ylamine Dihydrochloride
CAS No.	936233-12-4
Molecular Formula	C₁₃H₁₇N₃O₂S • 2HCl
Molecular Weight	368.28 g/mol (for dihydrochloride salt)
Synonyms	(S)-3-Amino-1-(isoquinolin-5-ylsulfonyl)pyrrolidine dihydrochloride; (S)-1-(Isoquinoline-5-sulfonyl)pyrrolidin-3-amine dihydrochloride; (S)-Pyrrolidin-3-ylamine, 1-(5-isoquinolinesulfonyl)-, dihydrochloride; 5-Isoquinolinesulfonamide, N-[(3S)-3-aminopyrrolidinyl]-, dihydrochloride; (S)-1-(5-Isoquinolinesulfonyl)-3-aminopyrrolidine dihydrochloride; (S)-3-Amino-N-(isoquinolin-5-ylsulfonyl)pyrrolidine dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-1-(Isoquinoline-5-Sulfonyl)-Pyrrolidin-3-Ylamine Dihydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Production adheres to cGMP guidelines where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.