Description

(R)-Isoquinoline-5-Sulfonic Acid (Piperidin-3-Ylmethyl)-Amide Dihydrochloride is a high-purity, chiral organic compound primarily utilized as a sophisticated building block in pharmaceutical research and development. Its value lies in its specific stereochemistry and functional groups, which make it a critical intermediate for synthesizing novel active pharmaceutical ingredients (APIs) targeting complex diseases. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who are developing new therapeutic agents, particularly in areas requiring precise molecular recognition.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) in pre-clinical and clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Process Chemistry Development: Serves as a critical starting material or intermediate in the scale-up and optimization of synthetic routes for potential drug candidates.
• Biochemical Research: Potential use as a tool compound or probe in biochemical assays to study enzyme inhibition or receptor binding, given its specific sulfonamide and piperidine motifs.
• Asymmetric Synthesis: Employed in the development of new catalytic asymmetric reactions due to its defined (R)-configuration.

Basic Information

Product Name	(R)-Isoquinoline-5-Sulfonic Acid (Piperidin-3-Ylmethyl)-Amide Dihydrochloride
CAS No.	936233-11-3
Molecular Formula	C15H21N3O2S · 2HCl
Molecular Weight	396.33 g/mol (free base: 307.41 g/mol)
Synonyms	(R)-N-[(3-Piperidinyl)methyl]-5-isoquinolinesulfonamide dihydrochloride; (R)-5-Isoquinolinesulfonic acid (3-piperidinylmethyl)amide dihydrochloride; (R)-IKI-5; (R)-IKI5; (R)-5-ISO dihydrochloride; (R)-5-Isoquinolinesulfonamide derivative; (R)-PIQ-5-Sulfonamide dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Isoquinoline-5-Sulfonic Acid (Piperidin-3-Ylmethyl)-Amide Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm enantiomeric purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.