Description

(R)-4-(Isoquinoline-5-Sulfonyl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester Dihydrochloride is a high-purity chiral building block and advanced pharmaceutical intermediate of significant importance in modern drug discovery. Its value lies in its defined stereochemistry and functionalized piperazine core, which are critical for the synthesis of targeted bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly those focused on developing novel therapeutics in areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for targeted therapies.
• Drug Discovery Scaffold: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization due to its versatile piperazine-sulfonamide structure.
• Protease Inhibitor Synthesis: Serves as a critical precursor in the synthesis of potential protease inhibitors, given the common isoquinoline sulfonamide pharmacophore.
• Kinase Inhibitor Development: Employed in the construction of novel kinase inhibitor candidates for oncology research programs.
• Chemical Biology Probes: Utilized as a building block for creating specialized chemical probes to study enzyme function and biological pathways.
• Process Chemistry: Acts as an intermediate in the scale-up and process development for potential clinical trial materials.

Basic Information

Item	Details
Product Name	(R)-4-(Isoquinoline-5-Sulfonyl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester Dihydrochloride
CAS No.	936233-10-2
Molecular Formula	C19H26Cl2N4O4S
Molecular Weight	477.41 g/mol
Synonyms	(R)-3-Methyl-1-((5-isoquinolinyl)sulfonyl)-4-piperazinecarboxylic acid 1,1-dimethylethyl ester dihydrochloride; tert-Butyl (R)-3-methyl-4-(isoquinoline-5-sulfonyl)piperazine-1-carboxylate dihydrochloride; (R)-N-Boc-3-methyl-4-(isoquinoline-5-sulfonyl)piperazine dihydrochloride; (R)-4-(Isoquinolin-5-ylsulfonyl)-3-methylpiperazine-1-carboxylic acid tert-butyl ester dihydrochloride; (R)-Tert-butyl 3-methyl-4-(isoquinoline-5-sulfonyl)piperazine-1-carboxylate dihydrochloride; (R)-Boc-3-methyl-4-(5-isoquinolinesulfonyl)piperazine di-HCl
EINECS	Contact for details

Quality Control

Our (R)-4-(Isoquinoline-5-Sulfonyl)-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester Dihydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and comprehensive identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, purity, and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.