Description

(S)-Isoquinoline-5-Sulfonic Acid (Piperidin-3-Ylmethyl)-Amide Dihydrochloride is a high-purity, chiral organic compound of significant interest in advanced pharmaceutical research and development. Its value lies in its role as a sophisticated chemical building block for creating novel, targeted therapeutic agents. This product is essential for R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors, particularly those focused on medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Process Chemistry Development: Serves as a critical starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.
• Biochemical Tool Compound: Potential use in developing enzyme inhibitors or receptor modulators for biochemical and pharmacological assays.
• Custom Synthesis & Contract Manufacturing: A high-value intermediate for custom synthesis houses serving the pharmaceutical industry's need for complex, proprietary molecules.

Basic Information

Product Name	(S)-Isoquinoline-5-Sulfonic Acid (Piperidin-3-Ylmethyl)-Amide Dihydrochloride
CAS No.	936233-09-9
Molecular Formula	C15H21N3O2S • 2HCl
Molecular Weight	392.34 g/mol (free base: 307.41 g/mol)
Synonyms	(S)-5-[(3-Piperidinylmethyl)aminosulfonyl]isoquinoline Dihydrochloride; (S)-N-[(Piperidin-3-yl)methyl]isoquinoline-5-sulfonamide Dihydrochloride; (S)-Isoquinoline-5-sulfonic acid (3-piperidinylmethyl)-amide Dihydrochloride; (S)-PIQSA Dihydrochloride; (S)-IQSA-Pip Dihydrochloride; (S)-5-(Piperidin-3-ylmethylsulfamoyl)isoquinoline Dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Isoquinoline-5-Sulfonic Acid (Piperidin-3-Ylmethyl)-Amide Dihydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. Our quality systems are designed to support development from non-GMP research through to GMP-grade material for advanced clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.