Description

(R)-Isoquinoline-5-Sulfonic Acid Piperidin-3-Ylamide Dihydrochloride is a high-purity chiral chemical building block and research compound. This compound is valued for its role as a key synthetic intermediate in the development of novel pharmaceutical agents, particularly in medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of potential drug candidates, especially in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic entities.
• Process Chemistry Development: Serves as a starting material or advanced intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Biochemical Tool Compound: Employed in vitro and in vivo to study specific biological pathways and protein interactions.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Asymmetric Synthesis: Leverages its chiral (R)-configuration for the construction of enantiomerically pure complex molecules.

Basic Information

Product Name	(R)-Isoquinoline-5-Sulfonic Acid Piperidin-3-Ylamide Dihydrochloride
CAS No.	936233-06-6
Molecular Formula	C₁₈H₂₂Cl₂N₄O₂S
Molecular Weight	429.36 g/mol
Synonyms	(R)-5-(3-Aminopiperidin-1-ylsulfonyl)isoquinoline dihydrochloride; (R)-Isoquinoline-5-sulfonic acid (3-amino-piperidin-1-yl)-amide dihydrochloride; (R)-1-(Isoquinolin-5-ylsulfonyl)piperidin-3-amine dihydrochloride; UNII-9K3S6V2A8F; 936233-06-6; (R)-5-[(3-Aminopiperidin-1-yl)sulfonyl]isoquinoline dihydrochloride; (R)-5-(3-Aminopiperidine-1-sulfonyl)isoquinoline dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Isoquinoline-5-Sulfonic Acid Piperidin-3-Ylamide Dihydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including those for early-phase GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Chiral Purity (Chiral HPLC)	≥98.0% ee

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.