Description

(S)-5-(Piperidine-1-Sulfonyl)-Isoquinoline Dihydrochloride CAS NO 936233-05-5 is a high-purity, chiral organic compound featuring a piperidine-sulfonyl-isoquinoline core structure. This compound is a critical building block and intermediate in advanced pharmaceutical research and development, particularly for the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and contract research and manufacturing organizations (CROs/CMOs) engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Protease Inhibitor Development: The sulfonyl and isoquinoline motifs suggest potential application in the design of enzyme inhibitors.
• Kinase Inhibitor Scaffold: Serves as a core structure for developing selective kinase inhibitors in oncology and inflammatory disease research.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological processes and target validation.
• Process Chemistry: Employed in route scouting and scale-up studies for active pharmaceutical ingredient (API) manufacturing.

Basic Information

Item	Detail
Product Name	(S)-5-(Piperidine-1-Sulfonyl)-Isoquinoline Dihydrochloride
CAS No.	936233-05-5
Molecular Formula	C₁₄H₁₈N₂O₂S·2HCl
Molecular Weight	363.29 g/mol (Free base: 278.37 g/mol)
Synonyms	(S)-5-(1-Piperidinesulfonyl)isoquinoline dihydrochloride; (S)-5-(Piperidine-1-sulfonyl)isoquinoline hydrochloride; 5-(Piperidin-1-ylsulfonyl)isoquinoline, (S)-, dihydrochloride; 936233-05-5; UNII-9F8V2Y1V1F; 9F8V2Y1V1F; SCHEMBL21806427; A1-00327
EINECS	Contact for details

Quality Control

Our (S)-5-(Piperidine-1-Sulfonyl)-Isoquinoline Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.