Description

(S)-2-Methyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a chiral, non-proteinogenic amino acid derivative belonging to the tetrahydroisoquinoline class of compounds. This high-purity building block is critical for the synthesis of complex molecules where stereochemical integrity is paramount. It is primarily sought after by pharmaceutical and biotechnology research organizations for the development of new active pharmaceutical ingredients (APIs), particularly in areas like neurology and oncology.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) targets.
• Peptidomimetics: Used to incorporate constrained, rigid structures into peptide backbones to enhance stability, bioavailability, and receptor selectivity.
• Asymmetric Synthesis: Serves as a valuable chiral auxiliary or starting material in stereoselective chemical transformations.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical spaces and optimize lead compounds.
• Bioconjugation: Potential use in creating labeled probes or antibody-drug conjugates (ADCs) due to its carboxylic acid functionality.
• Chemical Biology: Useful as a tool compound for studying enzyme mechanisms or protein-ligand interactions.

Basic Information

Product Name	(S)-2-Methyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	936213-74-0
Molecular Formula	C11H13NO2
Molecular Weight	191.23 g/mol
Synonyms	(3S)-2-Methyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; (S)-2-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (S)-2-Methyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; (S)-2-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; L-2-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (S)-MTIQ; (S)-2-Me-Tic-OH
EINECS	Contact for details

Quality Control

Our (S)-2-Methyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.