Description

4-(5-Fluoro-1H-Indol-3-Yl)-3,6-Dihydro-2H-Pyridine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for research and development in modern drug discovery. This compound is a critical building block for medicinal chemists, offering a versatile scaffold for the synthesis of novel bioactive molecules. It is primarily utilized in the development of targeted therapies within the pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of heterobifunctional molecules designed for targeted protein degradation.
• Kinase Inhibitor Synthesis: Employed in the creation of selective kinase inhibitors due to the indole-pyridine hybrid structure.
• Contract Research & Manufacturing (CRMO): Supplied to organizations specializing in custom synthesis and scale-up of active pharmaceutical ingredients (APIs).
• Academic Research: Used in university and institutional labs for exploratory research in organic synthesis and pharmacology.

Basic Information

Product Name	4-(5-Fluoro-1H-Indol-3-Yl)-3,6-Dihydro-2H-Pyridine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	935678-62-9
Molecular Formula	C18H21FN2O2
Molecular Weight	316.37 g/mol
Synonyms	tert-Butyl 4-(5-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-carboxylate; 1-Boc-4-(5-fluoro-1H-indol-3-yl)-1,2,3,6-tetrahydropyridine; 4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl 4-(5-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-carboxylate; 5-Fluoro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole-1-carboxylic acid tert-butyl ester (tautomeric form); Boc-4-(5-Fluoro-indol-3-yl)-3,6-dihydro-2H-pyridine; 935678-62-9
EINECS	Contact for details

Quality Control

Our production of 4-(5-Fluoro-1H-Indol-3-Yl)-3,6-Dihydro-2H-Pyridine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality protocols suitable for pharmaceutical R&D. Every batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (by NMR and IR), and impurity profiles are provided with each shipment. Our quality system supports compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.