Description

L-Serine-D7 is a stable isotope-labeled analog of the essential amino acid L-serine, where seven hydrogen atoms are replaced by deuterium. This high-purity compound is critical for advanced research requiring precise metabolic and pharmacokinetic tracing. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications such as mass spectrometry-based quantification and metabolic pathway studies.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a crucial quantitative reference in LC-MS and GC-MS analyses for accurate measurement of endogenous L-serine levels in complex biological matrices.
• Metabolic Research & Tracer Studies: Used to investigate serine metabolism, biosynthesis pathways, and one-carbon unit transfer in cell culture, animal models, and clinical research.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of serine-related drug candidates.
• Biochemical Assay Development: Acts as a labeled substrate or standard in enzymatic assays to study serine hydroxymethyltransferase (SHMT) and other serine-involving enzymes.
• NMR Spectroscopy: Useful as a deuterated standard in nuclear magnetic resonance (NMR) spectroscopy to aid in structural elucidation and method development.
• Nutritional Science Research: Applied in studies examining the role of serine in human nutrition, cellular signaling, and neurotransmitter synthesis.

Basic Information

Product Name	L-Serine-D7
CAS No.	935275-35-7
Molecular Formula	C3H2D7NO3
Molecular Weight	112.13 g/mol
Synonyms	(2S)-2-Amino-3-hydroxypropanoic-2,3,3-d3-1,1,2,2-d4 acid; (S)-2-Amino-3-hydroxypropionic-d7 acid; L-Serine-d7; Deuterated L-Serine; Serine (U-D7); L-2-Amino-3-hydroxypropionic-d7 acid; (S)-Serine-d7; [U-D7]-L-Serine
EINECS	Contact for details

Quality Control

Every batch of L-Serine-D7 is manufactured and tested under strict quality management protocols to ensure exceptional isotopic and chemical purity. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing isotopic enrichment (atom % D), chemical purity, and specific analytical data are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Optical Rotation	[α]20/D: +13.5° to +15.5° (c=1 in 1N HCl)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.