Description

1-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenoxy)ethyl)piperidine is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical manufacturers in the development of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those requiring biaryl linkages.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl halides and boronic acids/esters under mild conditions.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies for new molecular entities.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands or catalysts in asymmetric synthesis.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and polymers.
• Agrochemical Synthesis: Intermediate in the development of new herbicides or fungicides with specific activity profiles.

Basic Information

Product Name	1-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenoxy)ethyl)piperidine
CAS No.	934586-49-9
Molecular Formula	C19H30BNO3
Molecular Weight	331.26 g/mol
Synonyms	1-[2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]piperidine; 2-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(2-Piperidin-1-ylethoxy)phenylboronic acid pinacol ester; Piperidine, 1-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]-; 934586-49-9; BRN 15429035
EINECS	Contact for details

Quality Control

Our 1-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenoxy)ethyl)piperidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.