Description

3,5-Difluorobenzoic-D3 Acid is a deuterium-labeled derivative of 3,5-difluorobenzoic acid, where three hydrogen atoms are replaced with the stable isotope deuterium. This compound is a critical analytical standard and building block for research in pharmaceutical development and metabolic studies. It is primarily used by scientists and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors who require isotopically labeled compounds for precise quantification, tracer studies, and the synthesis of deuterated active pharmaceutical ingredients (APIs).

Application

• Internal Standard for LC-MS/MS Analysis: Essential for the accurate quantification of 3,5-difluorobenzoic acid and its metabolites in complex biological matrices like plasma and urine.
• Deuterated Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of deuterium-labeled drug candidates, which can offer improved metabolic stability and pharmacokinetic profiles.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of molecules within biological systems.
• Agrochemical Research: Employed in the development and analysis of novel fluorinated and deuterated agrochemicals.
• NMR Spectroscopy Solvent & Reagent: Useful as a probe or reagent in nuclear magnetic resonance (NMR) spectroscopy due to its distinct isotopic signature.
• Material Science Research: Acts as a monomer or modifying agent in the development of specialized fluorinated polymers and advanced organic materials.

Basic Information

Product Name	3,5-Difluorobenzoic-D3 Acid
CAS No.	934397-71-4
Molecular Formula	C7D3F2O2
Molecular Weight	163.11 g/mol
Synonyms	Benzoic-2,4,6-D3 acid, 3,5-difluoro-; 3,5-Difluorobenzoic-2,4,6-d3 Acid; Deuterated 3,5-Difluorobenzoic Acid; 3,5-Difluoro-d3-benzoic Acid; (2,4,6-Trideuterio-3,5-difluorophenyl)formic acid; 3,5-Difluorobenzoic Acid (phenyl-D3); 3,5-DFBA-D3
EINECS	Contact for details

Quality Control

Our 3,5-Difluorobenzoic-D3 Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including NMR and HPLC/MS, to confirm isotopic purity (D-enrichment ≥ 98 atom % D) and chemical purity (typically ≥97%). Certificates of Analysis (COA) detailing batch-specific results for identity, assay, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity (by HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.