Description

Isoquinoline-5-Sulfonic Acid-n-Methyl-(Piperidin-4-Yl)-Amide Dihydrochloride is a high-purity, specialized organic intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in advanced pharmaceutical research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, focusing on areas such as kinase inhibitor development and central nervous system (CNS) targeting therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Used in vitro to study biological pathways and enzyme interactions relevant to disease mechanisms.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the production of bespoke compounds for client projects.

Basic Information

Product Name	Isoquinoline-5-Sulfonic Acid-n-Methyl-(Piperidin-4-Yl)-Amide Dihydrochloride
CAS No.	934349-13-0
Molecular Formula	C16H22Cl2N4O3S
Molecular Weight	421.34 g/mol
Synonyms	5-[(Methyl(piperidin-4-yl)amino)sulfonyl]isoquinoline dihydrochloride; N-Methyl-N-(piperidin-4-yl)isoquinoline-5-sulfonamide dihydrochloride; Isoquinoline-5-sulfonic acid methyl-piperidin-4-yl-amide dihydrochloride; UNII-8V6C8QZ5QO; 934349-13-0; 5-(N-Methyl-N-(4-piperidyl)sulfamoyl)isoquinoline dihydrochloride
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Our standard grade typically meets a purity specification of ≥95% (by HPLC), with options for higher grades available. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.