Description

Rabeprazole-D4 is a deuterium-labeled analog of the proton pump inhibitor rabeprazole, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS, by correcting for variations in sample preparation and instrument response. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control departments for pharmacokinetic studies, bioequivalence testing, and metabolite profiling.

Application

• Internal Standard for LC-MS/MS quantification of rabeprazole and its metabolites in biological matrices (plasma, serum, urine).
• Use in pharmacokinetic and pharmacodynamic (PK/PD) studies during drug development.
• Bioanalytical method development and validation for generic drug applications.
• Quality control and assurance testing in pharmaceutical manufacturing.
• Metabolite identification and profiling in preclinical and clinical research.
• Stability-indicating assay methods for rabeprazole-containing formulations.

Basic Information

Product Name	Rabeprazole-D4
CAS No.	934295-48-4
Molecular Formula	C18H17D4N3O3S
Molecular Weight	383.46 g/mol (deuterated form)
Synonyms	2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole-d4; Rabeprazole Deuterated; Rabeprazole Internal Standard; Rabeprazole-d4; Pariet-d4; Aciphex-d4; LY307640-d4
EINECS	Contact for details

Quality Control

Our Rabeprazole-D4 is manufactured under strict quality control protocols to ensure the highest standards of chemical purity and isotopic enrichment, which are critical for its function as an analytical standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), deuterium enrichment (by NMR or MS), and identity confirmation. We adhere to cGMP guidelines where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.