Description

Omeprazole-D3 is a deuterium-labeled analog of the proton pump inhibitor omeprazole, where three hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is an essential internal standard for the accurate quantification of omeprazole in biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for pharmaceutical research and development, clinical pharmacology, and bioanalytical laboratories. The product is supplied with guaranteed high chemical and isotopic purity to ensure reliable and reproducible results.

Application

• Bioanalytical Internal Standard: Primary use as a stable isotope-labeled internal standard for the precise quantification of omeprazole in pharmacokinetic and pharmacodynamic studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Clinical Trial Support: Used in bioanalytical method development and validation to ensure data integrity for regulatory submissions to agencies like the FDA and EMA.
• Forensic and Toxicology Analysis: Assists in the specific and sensitive detection of omeprazole in complex biological samples.
• Pharmaceutical Quality Control: Can be utilized in method development for impurity profiling and assay of omeprazole in finished drug products.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the ideal spike for achieving the highest accuracy in quantitative mass spectrometric analyses.

Basic Information

Product Name	Omeprazole-D3
CAS No.	934293-91-1
Molecular Formula	C17H16D3N3O3S
Molecular Weight	348.42 g/mol
Synonyms	5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl-d3)methyl]sulfinyl]-1H-benzimidazole; Deuterated Omeprazole; Omeprazole (methyl-d3); Omeprazole-d3; [2H3]-Omeprazole; (RS)-Omeprazole-d3; 6-Methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl-d3)methylsulfinyl]-1H-benzimidazole
EINECS	Contact for details

Quality Control

Every batch of Omeprazole-D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment to meet the exacting demands of quantitative bioanalysis. Our quality protocols include rigorous identity confirmation, purity assessment, and verification of isotopic purity by techniques such as NMR and MS. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and impurities is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.