Description

3-Cyano-6-(Trifluoromethyl)-1H-Indole is a high-value, multi-functional heterocyclic building block characterized by its indole core, cyano, and trifluoromethyl substituents. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, where its unique structure enables the introduction of key pharmacophores and modulates physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Research: Used in the synthesis of advanced pesticides and herbicides, leveraging the trifluoromethyl group for enhanced bioactivity and environmental stability.
• Material Science Precursor: Serves as a building block for functionalized polymers and organic electronic materials due to its electron-withdrawing groups.
• Chemical Biology Probes: Utilized in the design of fluorescent tags and molecular probes for studying biological processes.
• Catalyst & Ligand Development: Acts as a precursor for novel N-heterocyclic carbene (NHC) ligands or organocatalysts.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthesis projects requiring specialized indole derivatives.

Basic Information

Product Name	3-Cyano-6-(Trifluoromethyl)-1H-Indole
CAS No.	934290-68-3
Molecular Formula	C10H5F3N2
Molecular Weight	210.16 g/mol
Synonyms	6-(Trifluoromethyl)-1H-indole-3-carbonitrile; 3-Cyano-6-(trifluoromethyl)indole; 1H-Indole-3-carbonitrile, 6-(trifluoromethyl)-; 6-Trifluoromethyl-1H-indole-3-carbonitrile; 6-Trifluoromethylindole-3-carbonitrile; 3-Cyano-6-trifluoromethylindole; 934290-68-3; 6-(Trifluoromethyl)indole-3-carbonitrile
EINECS	Contact for details

Quality Control

Our 3-Cyano-6-(Trifluoromethyl)-1H-Indole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.