Description

1-(7-Chloro-1H-Indol-3-Yl)-2,2,2-Trifluoroethanone is a high-purity, trifluoromethylated indole derivative of significant interest in advanced organic synthesis. This compound serves as a critical building block for the development of novel pharmaceutical intermediates and agrochemicals, where the introduction of the trifluoromethyl group is known to enhance metabolic stability and bioavailability. It is primarily utilized by research institutions and industrial R&D departments focused on medicinal chemistry, particularly in the synthesis of bioactive molecules targeting central nervous system disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting serotonin receptors and other neurological pathways.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging the biological activity of the indole scaffold.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Employed in organic synthesis for the construction of complex heterocyclic compounds and fluorinated analogs.
• Biochemical Research: Used as a reference standard or probe in biochemical assays to study enzyme inhibition and receptor binding.
• Material Science: Potential intermediate for the synthesis of specialty chemicals and advanced organic materials.

Basic Information

Item	Detail
Product Name	1-(7-Chloro-1H-Indol-3-Yl)-2,2,2-Trifluoroethanone
CAS No.	934185-80-5
Molecular Formula	C10H5ClF3NO
Molecular Weight	247.60 g/mol
Synonyms	7-Chloro-3-(trifluoroacetyl)indole; 1-(7-Chloro-1H-indol-3-yl)-2,2,2-trifluoroethan-1-one; 7-Chloro-3-trifluoroacetylindole; 2,2,2-Trifluoro-1-(7-chloro-1H-indol-3-yl)ethanone; 7-Chloroindole-3-trifluoromethyl ketone; 7-Chloro-α,α,α-trifluoro-1H-indole-3-acetophenone
EINECS	Contact for details

Quality Control

Our 1-(7-Chloro-1H-Indol-3-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.