Description

11H-Pyrrolo[2,1-C][1,4]Benzodiazepin-11-One, 1,2,3,5,10,11A-Hexahydro-, (11Ar)- is a complex, heterocyclic organic compound belonging to the benzodiazepine class, identified by CAS number 933981-46-5. This high-purity intermediate is of significant value in pharmaceutical research and development, particularly for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating new therapeutic agents targeting the central nervous system and other disease areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel benzodiazepine-derived active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	11H-Pyrrolo[2,1-C][1,4]Benzodiazepin-11-One, 1,2,3,5,10,11A-Hexahydro-, (11Ar)-
CAS No.	933981-46-5
Molecular Formula	C14H14N2O
Molecular Weight	226.27 g/mol
Synonyms	(11aR)-1,2,3,5,10,11a-Hexahydro-11H-pyrrolo[2,1-c][1,4]benzodiazepin-11-one; (R)-1,2,3,5,10,11a-Hexahydro-11H-pyrrolo[2,1-c][1,4]benzodiazepin-11-one; 11H-Pyrrolo[2,1-c][1,4]benzodiazepin-11-one, 1,2,3,5,10,11a-hexahydro-, (11aR)-; Hexahydro-pyrrolobenzodiazepinone; PBD Intermediate; Benzodiazepine Fused Pyrrolidine Derivative
EINECS	Contact for details

Quality Control

Our 11H-Pyrrolo[2,1-C][1,4]Benzodiazepin-11-One, 1,2,3,5,10,11A-Hexahydro-, (11Ar)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification and impurity profiling. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or development specifications. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.