Description

1H-Benzimidazole, 7-Methoxy-2-(2-Pyrrolidinyl)- is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzimidazole core fused with pyrrolidine and methoxy substituents. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Development: Integral in the process development and scale-up of new benzimidazole-derived active pharmaceutical ingredients.
• Biochemical Research: May be employed as a tool compound or ligand in biochemical assays and proteomics research due to its specific structural motifs.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis projects under cGMP or non-GMP conditions, depending on the project phase.

Basic Information

Product Name	1H-Benzimidazole, 7-Methoxy-2-(2-Pyrrolidinyl)-
CAS No.	933709-61-6
Molecular Formula	C₁₂H₁₅N₃O
Molecular Weight	217.27 g/mol
Synonyms	7-Methoxy-2-(pyrrolidin-2-yl)-1H-benzimidazole; 2-(2-Pyrrolidinyl)-7-methoxy-1H-benzimidazole; 7-Methoxy-2-(2-pyrrolidinyl)benzimidazole; 1H-Benzimidazole, 7-methoxy-2-(2-pyrrolidinyl)-; 933709-61-6; 7-Methoxy-2-pyrrolidin-2-yl-1H-benzo[d]imidazole
EINECS	Contact for details

Quality Control

Our 1H-Benzimidazole, 7-Methoxy-2-(2-Pyrrolidinyl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support development with regulatory documentation as needed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.