Description

Duloxetine n-Methyl (R)-Isomer is a high-purity chiral intermediate and stereoisomer of the active pharmaceutical ingredient duloxetine. This compound is of critical importance for research and development in enantioselective synthesis and for the production of optically pure active metabolites or related pharmacologically active substances. It is primarily needed by pharmaceutical R&D laboratories, process chemistry teams, and fine chemical manufacturers focused on developing novel serotonin-norepinephrine reuptake inhibitors (SNRIs) and other central nervous system (CNS) targeted therapies.

Application

• Pharmaceutical Intermediate: Key chiral building block in the research and synthesis of duloxetine analogs and metabolites.
• Process Chemistry R&D: Used for developing and optimizing enantioselective synthetic routes in laboratory-scale and pilot-scale studies.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in chiral separation techniques like HPLC and SFC.
• Metabolite Studies: Employed in pharmacological and toxicological research to study the activity and disposition of specific duloxetine isomers.
• Asymmetric Synthesis: Valuable substrate for exploring new catalytic asymmetric transformations in academic and industrial settings.
• Impurity Profiling: Used to identify, quantify, and qualify stereoisomeric impurities in duloxetine active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Duloxetine n-Methyl (R)-Isomer
CAS No.	932013-45-1
Molecular Formula	C19H21NOS
Molecular Weight	311.44 g/mol
Synonyms	(R)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine; (R)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine; (R)-Duloxetine N-Methyl Isomer; (R)-LY248686 N-Methyl Derivative; (R)-N-Methyl Duloxetine; (3R)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine
EINECS	Contact for details

Quality Control

Our Duloxetine n-Methyl (R)-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for research and development use. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.