Description

L-Aminobutyric Acid-D3 is a stable isotope-labeled analog of the neurotransmitter γ-aminobutyric acid (GABA), where three hydrogen atoms are replaced by deuterium. This high-purity labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is a critical reagent for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors who require precise quantification of GABA and related metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application for the accurate quantification of endogenous GABA levels in complex biological matrices like plasma, serum, cerebrospinal fluid, and tissue homogenates.
• Pharmacokinetic & Metabolomic Studies: Used in drug development to track the metabolism of GABAergic drugs and to study metabolic pathways in neurological disorders.
• Clinical Diagnostics: Enables precise measurement of GABA for research into conditions such as epilepsy, anxiety, depression, and Parkinson's disease.
• Biochemical Research: Serves as a tracer in enzymatic assays and studies of GABA synthesis, release, uptake, and catabolism.
• Quality Control & Method Validation: Critical for developing, validating, and ensuring the compliance of analytical methods in GMP/GLP environments.
• Neuroscience & Neuropharmacology: A key tool for investigating the role of GABA in synaptic transmission, neuronal excitability, and the mechanism of action of therapeutic agents.

Basic Information

Product Name	L-Aminobutyric Acid-D3
CAS No.	929202-07-3
Molecular Formula	C₄H₆D₃NO₂
Molecular Weight	107.12 g/mol
Synonyms	(3S)-4-Amino-3-hydroxybutanoic acid-d3; L-Homoserine-d3; (S)-2-Amino-4-hydroxybutyric acid-d3; L-2-Amino-4-hydroxybutyric acid-d3; L-α-Amino-γ-hydroxybutyric acid-d3; GABA-d3 (L-isomer); Stable Isotope Labeled GABA; Deuterated L-Homoserine
EINECS	Contact for details

Quality Control

Our L-Aminobutyric Acid-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced techniques including NMR, HPLC, and mass spectrometry to confirm identity, chemical purity, and deuterium enrichment. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (e.g., D ≥ 98%), chemical purity (typically ≥ 98%), and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D)	≥ 98 atom % D
Chemical Purity	≥ 98%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.