Description

(R)-Methyl 5-(6-(Chloromethyl)-1H-Benzo[D]Imidazol-1-Yl)-3-(1-(2-(Trifluoromethyl)Phenyl)Ethoxy)Thiophene-2-Carboxylate is a high-value, non-racemic chiral intermediate of significant interest in advanced pharmaceutical research and development. Its complex molecular architecture, featuring a benzimidazole core linked to a substituted thiophene carboxylate, makes it a critical building block for synthesizing targeted bioactive molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs) requiring a specific (R)-enantiomer configuration for optimal biological activity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore and optimize the efficacy and selectivity of lead compounds.
• Process Chemistry & Scale-Up: Acts as a defined starting material or intermediate in process route development and optimization for GMP manufacturing.
• Biochemical Probe Development: Can be utilized to create specialized probes for studying enzyme mechanisms or receptor interactions in biochemical assays.

Basic Information

Product Name	(R)-Methyl 5-(6-(Chloromethyl)-1H-Benzo[D]Imidazol-1-Yl)-3-(1-(2-(Trifluoromethyl)Phenyl)Ethoxy)Thiophene-2-Carboxylate
CAS No.	929095-40-9
Molecular Formula	C23H18ClF3N2O3S
Molecular Weight	494.91 g/mol
Synonyms	Methyl (R)-5-[6-(chloromethyl)-1H-benzimidazol-1-yl]-3-[1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxylate; 929095-40-9; (R)-enantiomer of Methyl 5-(6-(Chloromethyl)-1H-Benzoimidazol-1-Yl)-3-(1-(2-(Trifluoromethyl)Phenyl)Ethoxy)Thiophene-2-Carboxylate; Benzimidazole-thiophene carboxylate intermediate; SCHEMBL21806227; AKOS040759623; FT-0773290; EN300-131340
EINECS	Contact for details

Quality Control

Our (R)-Methyl 5-(6-(Chloromethyl)-1H-Benzo[D]Imidazol-1-Yl)-3-(1-(2-(Trifluoromethyl)Phenyl)Ethoxy)Thiophene-2-Carboxylate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and isomeric purity suitable for demanding research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.