Description

(R)-Methyl 5-(2-Nitro-5-(Pivaloyloxymethyl)Phenylamino)-3-(1-(2-(Trifluoromethyl)Phenyl)Ethoxy)Thiophene-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex chiral structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high stereochemical purity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Preclinical & Clinical Research: Used in the discovery and development phases for creating novel therapeutic candidates with specific biological activity.
• Process Chemistry & Scale-Up: Serves as a critical intermediate for process research and development (PR&D) and the scale-up to commercial manufacturing.
• Targeted Drug Synthesis: Employed in constructing complex molecular architectures for drugs targeting specific receptors or enzymes.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API production.
• Academic & Contract Research: Used in university laboratories and CROs (Contract Research Organizations) for medicinal chemistry programs.

Basic Information

Product Name	(R)-Methyl 5-(2-Nitro-5-(Pivaloyloxymethyl)Phenylamino)-3-(1-(2-(Trifluoromethyl)Phenyl)Ethoxy)Thiophene-2-Carboxylate
CAS No.	929095-36-3
Molecular Formula	C27H27F3N2O6S
Molecular Weight	564.58 g/mol
Synonyms	(R)-Methyl 5-((2-nitro-5-((2,2-dimethylpropanoyloxy)methyl)phenyl)amino)-3-((1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate; 929095-36-3; (R)-Methyl 5-(2-Nitro-5-(Pivaloyloxymethyl)Anilino)-3-(1-(2-(Trifluoromethyl)Phenyl)Ethoxy)Thiophene-2-Carboxylate; Thiophene-2-carboxylic acid, 5-[(2-nitro-5-[(2,2-dimethyl-1-oxopropoxy)methyl]phenyl)amino]-3-[[1-[2-(trifluoromethyl)phenyl]ethoxy]-, methyl ester, (R)-; Methyl (R)-5-{[2-nitro-5-(pivaloyloxymethyl)phenyl]amino}-3-{[1-(2-(trifluoromethyl)phenyl)ethoxy]}thiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our (R)-Methyl 5-(2-Nitro-5-(Pivaloyloxymethyl)Phenylamino)-3-(1-(2-(Trifluoromethyl)Phenyl)Ethoxy)Thiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (e.g., nitrogen or argon) in a freezer (-20°C).

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.