Description

2-Thiophenecarboxylic Acid, 5-Nitro-3-[(1R)-1-[2-(Trifluoromethyl)Phenyl]Ethoxy]-, Methyl Ester is a high-value, chiral synthetic intermediate characterized by its complex molecular architecture featuring a nitro-substituted thiophene core and a trifluoromethylphenyl ethoxy side chain. This compound matters for its role as a critical building block in the development of advanced pharmaceuticals and agrochemicals, where its specific stereochemistry and functional groups are essential for biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry, particularly those working on novel active pharmaceutical ingredients (APIs) and agrochemicals requiring sophisticated, multi-functional intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel drug candidates, especially in therapeutic areas targeting the central nervous system (CNS) and metabolic diseases.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl and nitro groups contribute to efficacy and environmental stability.
• Chemical Biology Probe Synthesis: Employed in the creation of specialized molecular probes for studying enzyme mechanisms and receptor interactions due to its distinct structural motifs.
• Material Science Research: Investigated as a monomer or precursor for functional polymers and advanced organic electronic materials, leveraging the thiophene backbone.
• Process Chemistry & Scale-Up: A critical component for process optimization and pilot-scale production runs for target molecules requiring this specific stereoisomer.

Basic Information

Item	Detail
Product Name	2-Thiophenecarboxylic Acid, 5-Nitro-3-[(1R)-1-[2-(Trifluoromethyl)Phenyl]Ethoxy]-, Methyl Ester
CAS No.	929039-94-1
Molecular Formula	C15H12F3NO5S
Molecular Weight	375.32 g/mol
Synonyms	Methyl 5-nitro-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxylate; (R)-Methyl 5-nitro-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate; 5-Nitro-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxylic acid methyl ester; 929039-94-1; (R)-enantiomer of the methyl ester; Chiral thiophene ester intermediate; Trifluoromethylphenyl ethoxy nitro thiophene carboxylate
EINECS	Contact for details

Quality Control

Our production of 2-Thiophenecarboxylic Acid, 5-Nitro-3-[(1R)-1-[2-(Trifluoromethyl)Phenyl]Ethoxy]-, Methyl Ester adheres to stringent quality protocols suitable for pharmaceutical R&D. Each batch undergoes rigorous analytical testing to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and chiral purity analysis. We support development under cGMP guidelines where required and ensure full traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled under an inert atmosphere if prolonged exposure is anticipated to prevent degradation. Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.