Description

2-Thiophenecarboxylic Acid, 5-Amino-3-[(1R)-1-[2-(Trifluoromethyl)Phenyl]Ethoxy]-, Methyl Ester is a high-purity, chiral organic intermediate of significant importance in modern synthetic chemistry. Its value lies in its complex molecular architecture, which incorporates a thiophene core, a trifluoromethylphenyl group, and a stereogenic center, making it a versatile building block for creating targeted bioactive molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for applications in medicinal chemistry and agrochemical research.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders or inflammatory diseases.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl and thiophene moieties can contribute to enhanced biological activity and environmental stability.
• Material Science Precursor: Acts as a specialized monomer or functionalizing agent in the synthesis of advanced polymers and organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions due to its unique structural features.
• Catalyst Ligand Development: The chiral center and heterocyclic structure make it a candidate for developing novel ligands for asymmetric catalysis.
• Custom Synthesis & Contract Manufacturing: A key material for fine chemical suppliers offering bespoke synthesis services for clients in the life sciences sector.

Basic Information

Product Name	2-Thiophenecarboxylic Acid, 5-Amino-3-[(1R)-1-[2-(Trifluoromethyl)Phenyl]Ethoxy]-, Methyl Ester
CAS No.	929039-92-9
Molecular Formula	C15H14F3NO3S
Molecular Weight	345.34 g/mol
Synonyms	Methyl 5-amino-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxylate; (R)-Methyl 5-amino-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate; 5-Amino-3-[(1R)-1-(2-trifluoromethylphenyl)ethoxy]thiophene-2-carboxylic acid methyl ester; CAS 929039-92-9; Chiral Thiophene Ester Intermediate; Trifluoromethylphenyl Ethoxy Thiophene Carboxylate
EINECS	Contact for details

Quality Control

Every batch of 2-Thiophenecarboxylic Acid, 5-Amino-3-[(1R)-1-[2-(Trifluoromethyl)Phenyl]Ethoxy]-, Methyl Ester is produced under strict quality management systems. Our products undergo rigorous analytical testing, including chiral purity analysis, to ensure compliance with exacting research and development standards. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with each shipment to guarantee traceability and consistency for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.