Description

1-Chloro-4-Fluoroisoquinolin-5-Amine is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its unique halogenated isoquinoline scaffold, which enables the construction of complex molecular architectures with targeted biological activity. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides due to its bioactive heterocyclic core.
• Material Science: Serves as a building block for creating specialized organic ligands and functional polymers.
• Chemical Biology: Employed as a probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Academic & Contract Research: Utilized in university and CRO laboratories for exploratory synthetic chemistry and methodological development.

Basic Information

Product Name	1-Chloro-4-Fluoroisoquinolin-5-Amine
CAS No.	928665-23-0
Molecular Formula	C9H6ClFN2
Molecular Weight	196.61 g/mol
Synonyms	5-Amino-1-chloro-4-fluoroisoquinoline; 1-Chloro-4-fluoro-5-aminoisoquinoline; 4-Fluoro-1-chloroisoquinolin-5-amine; 928665-23-0; 1-Chloro-4-fluoro-5-isoquinolinamine; 5-Isoquinolinamine, 1-chloro-4-fluoro-; 1-Chloro-4-fluoroisoquinolin-5-ylamine
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Fluoroisoquinolin-5-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep container tightly sealed under an inert atmosphere if long-term storage is required.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.