Description

Iothalamic Acid-D3 is a deuterium-labeled analog of the iodinated contrast agent iothalamic acid. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reproducibility. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and diagnostic manufacturers for method development, pharmacokinetic studies, and bioanalytical testing.

Application

• Internal standard for the quantitative LC-MS/MS analysis of iothalamic acid in biological matrices (e.g., plasma, urine).
• Method development and validation in pharmaceutical research and bioanalytical laboratories.
• Pharmacokinetic and metabolic studies to track the disposition of the parent compound.
• Quality control and assurance in the production of contrast media and related pharmaceuticals.
• Use in clinical research for accurate measurement of glomerular filtration rate (GFR) markers.
• Supporting regulatory submissions (e.g., to FDA, EMA) requiring validated bioanalytical methods.

Basic Information

Product Name	Iothalamic Acid-D3
CAS No.	928623-31-8
Molecular Formula	C11H6D3I3N2O4
Molecular Weight	628.89 g/mol
Synonyms	5-Acetamido-2,4,6-triiodo-N-methyl-D3-isophthalamic Acid; 3-(Acetylamino)-2,4,6-triiodo-5-[(methylamino-D3)carbonyl]benzoic Acid; Iothalamate-D3; Conray-D3; Deuterated Iothalamic Acid; [[(2,4,6-Triiodo-3-(acetylamino)-5-[(methyl-d3-amino)carbonyl]phenyl]carboxylic Acid; 5-Acetamido-2,4,6-triiodo-N-(trideuteriomethyl)isophthalamic Acid
EINECS	Contact for details

Quality Control

Our Iothalamic Acid-D3 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical and isotopic purity, NMR for structural confirmation, and mass spectrometry for identity verification. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.