Description

1H-Indazole-5-Propanoic Acid, α-Amino-7-Methyl-, Methyl Ester, Hydrochloride (1:1), (αr)- is a high-purity, non-racemic chiral building block of significant interest in advanced pharmaceutical research and development. This compound matters as a sophisticated synthetic intermediate, enabling the construction of complex molecules with specific stereochemistry for targeted biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel therapeutic agents, particularly those exploring indazole-based scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new drug candidates.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes for preclinical and clinical trial material production.
• Biochemical Tool Compound: Potential use in developing probes for studying enzyme mechanisms or receptor interactions where the indazole core is relevant.
• Asymmetric Synthesis: Utilized in reactions requiring a specific enantiomer to achieve desired stereochemical outcomes in complex molecule assembly.

Basic Information

Product Name	1H-Indazole-5-Propanoic Acid, α-Amino-7-Methyl-, Methyl Ester, Hydrochloride (1:1), (αr)-
CAS No.	928014-63-5
Molecular Formula	C₁₃H₁₇N₃O₂·HCl
Molecular Weight	283.75 g/mol (Free base: 247.29 g/mol)
Synonyms	(αR)-α-Amino-7-methyl-1H-indazole-5-propanoic acid methyl ester hydrochloride; Methyl (αR)-α-amino-7-methyl-1H-indazole-5-propanoate hydrochloride; (R)-Methyl 3-amino-3-(7-methyl-1H-indazol-5-yl)propanoate hydrochloride; (R)-Methyl 3-amino-3-(7-methyl-1H-indazol-5-yl)propionate hydrochloride; (R)-Methyl 3-(7-methyl-1H-indazol-5-yl)-3-aminopropanoate hydrochloride; AR-α-Amino-7-methyl-1H-indazole-5-propanoic acid methyl ester HCl; (R)-enantiomer of the methyl ester hydrochloride of the amino acid derivative.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of 1H-Indazole-5-Propanoic Acid, α-Amino-7-Methyl-, Methyl Ester, Hydrochloride (1:1), (αr)- is characterized and controlled to meet stringent specifications for identity, purity, and enantiomeric excess, suitable for research and development applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data, including HPLC purity and chiral assay, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.