Description

1-(Cyclopropylcarbonyl)Indolin-6-Amine is a high-purity organic compound featuring a unique indoline scaffold functionalized with a cyclopropylcarbonyl group and an amine. This specific molecular architecture makes it a valuable advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and for exploring new therapeutic pathways.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its modifiable amine and carbonyl functionalities.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating molecular probes to study biological pathways and protein functions.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects, offering a strategic point for diversification in complex molecule assembly.

Basic Information

Product Name	1-(Cyclopropylcarbonyl)Indolin-6-Amine
CAS No.	927996-96-1
Molecular Formula	C12H14N2O
Molecular Weight	202.25 g/mol
Synonyms	6-Amino-1-(cyclopropylcarbonyl)indoline; 1-(Cyclopropanecarbonyl)-2,3-dihydro-1H-indol-6-amine; 6-Amino-1-(cyclopropanecarbonyl)indoline; 1H-Indol-6-amine, 2,3-dihydro-1-(1-oxocyclopropyl)-; N-(Cyclopropylcarbonyl)indolin-6-amine; 1-(Cyclopropylcarbonyl)-2,3-dihydro-1H-indol-6-amine
EINECS	Contact for details

Quality Control

Our production of 1-(Cyclopropylcarbonyl)Indolin-6-Amine adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for critical research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development projects with custom synthesis and specification tailoring to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.