Description

Ethyl 4-Chlorobutyrate-D6 is a deuterium-labeled analog of ethyl 4-chlorobutyrate, serving as a critical stable isotope-labeled internal standard for precise analytical quantification. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based methods, particularly in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities focused on advanced bioanalysis and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard in quantitative bioanalysis for drug metabolism and pharmacokinetics (DMPK) studies.
• Pharmaceutical Impurity Reference: Acts as a reference standard for the identification and quantification of process-related impurities or metabolites in active pharmaceutical ingredients (APIs).
• Metabolite Tracing: Enables precise tracing and quantification of metabolites in complex biological matrices during preclinical and clinical research.
• Analytical Method Development: Critical for developing and validating sensitive and specific chromatographic methods (HPLC, GC) in regulatory environments.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy IDMS techniques for absolute quantification in research and quality control.

Basic Information

Product Name	Ethyl 4-Chlorobutyrate-D6
CAS No.	927810-76-2
Molecular Formula	C6H5D6ClO2 [C6H5ClO2 with six deuterium atoms]
Molecular Weight	~167.64 g/mol (deuterated form)
Synonyms	Ethyl 4-Chloro[2,2,3,3,4,4-2H6]butyrate; Ethyl 4-Chlorobutyrate-d6; Butanoic-2,2,3,3,4,4-d6 acid, 4-chloro-, ethyl ester; Deuterated Ethyl 4-Chlorobutyrate; Ethyl γ-Chlorobutyrate-D6; 4-Chlorobutanoic-2,2,3,3,4,4-d6 Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Chlorobutyrate-D6 is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity, meeting the stringent requirements of analytical reference standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from NMR (Nuclear Magnetic Resonance), HPLC/GC, and mass spectrometry for isotopic enrichment and chemical purity. We adhere to ISO 9001 quality management principles, and our processes are designed to support cGMP (current Good Manufacturing Practice) for investigational use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0% (chemical purity)
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.