Description

4-Iodoisoquinolin-1(2H)-One is a high-value halogenated isoquinoline derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both an iodine atom and a lactam moiety, makes it a versatile building block for constructing complex heterocyclic systems. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Building block for creating organic semiconductors, ligands for metal-organic frameworks (MOFs), and specialty polymers.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Chemical Biology: Used as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies.
• Academic & Contract Research: Essential reagent for methodological development and exploratory synthesis in university and CRO laboratories.

Basic Information

Product Name	4-Iodoisoquinolin-1(2H)-One
CAS No.	927801-74-9
Molecular Formula	C9H6INO
Molecular Weight	271.06 g/mol
Synonyms	4-Iodoisoquinolin-1(2H)-one; 4-Iodo-1H-isoquinolin-1-one; 4-Iodo-1,2-dihydroisoquinolin-1-one; 4-Iodo-2H-isoquinolin-1-one; 1(2H)-Isoquinolinone, 4-iodo-; 4-Iodo-1-isoquinolinol; 4-Iodo-1-hydroxyisoquinoline
EINECS	Contact for details

Quality Control

Every batch of 4-Iodoisoquinolin-1(2H)-One is manufactured and tested under strict quality management protocols to ensure consistency and reliability for research and development. We provide comprehensive analytical data including HPLC purity, NMR (1H and 13C), and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is available for each lot upon request, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.