Description

4-(Trifluoromethoxy)-1H-Indole-2-Carboxylic Acid is a high-value, multifunctional indole derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a carboxylic acid and a trifluoromethoxy group, makes it an essential intermediate for creating novel compounds with enhanced biological activity and physicochemical properties. This product is primarily targeted at research and development teams in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the synthesis of new-generation herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for improved metabolic stability and lipophilicity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic materials.
• Chemical Biology Probe: Employed in medicinal chemistry to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clients.

Basic Information

Product Name	4-(Trifluoromethoxy)-1H-Indole-2-Carboxylic Acid
CAS No.	926208-37-9
Molecular Formula	C10H6F3NO3
Molecular Weight	245.16 g/mol
Synonyms	4-(Trifluoromethoxy)-1H-indole-2-carboxylic acid; 2-Carboxy-4-(trifluoromethoxy)indole; 4-(Trifluoromethoxy)indole-2-carboxylic acid; 1H-Indole-2-carboxylic acid, 4-(trifluoromethoxy)-; 4-Trifluoromethoxyindole-2-carboxylic acid; 4-TFMICA; 4-(Trifluoromethoxy)indole-2-carboxylic acid, 926208-37-9
EINECS	Contact for details

Quality Control

Our production of 4-(Trifluoromethoxy)-1H-Indole-2-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, NMR, and MS, for comprehensive characterization and impurity profiling. A Certificate of Analysis (COA) detailing purity, identity, and specific tests is provided with each shipment and is available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.