Description

2-Thiophenesulfonyl Chloride, 5-(2H-Tetrazol-5-Yl)- is a high-value heterocyclic building block and sulfonyl chloride derivative that serves as a critical intermediate in modern synthetic chemistry. Its unique bifunctional structure, combining a reactive sulfonyl chloride group with a tetrazole moiety, makes it indispensable for constructing complex molecules with specific biological or material properties. This compound is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for applications in medicinal chemistry, catalyst design, and polymer synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of sulfonamide-based drugs and bioactive molecules containing tetrazole rings.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the sulfonyl chloride and tetrazole functionalities impart specific activity.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and functional materials.
• Medicinal Chemistry & Drug Discovery: A versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Utilized in the synthesis of affinity labels, enzyme inhibitors, and other biochemical tools due to its reactive groups.
• Coordination Chemistry: Acts as a ligand precursor for metal-organic frameworks (MOFs) and catalysts, leveraging the coordinating ability of the tetrazole nitrogen atoms.

Basic Information

Product Name	2-Thiophenesulfonyl Chloride, 5-(2H-Tetrazol-5-Yl)-
CAS No.	924964-21-6
Molecular Formula	C5H3ClN4O2S2
Molecular Weight	250.69 g/mol
Synonyms	5-(Tetrazol-5-yl)thiophene-2-sulfonyl chloride; 5-(1H-Tetrazol-5-yl)thiophene-2-sulfonyl chloride; 5-(2H-Tetrazol-5-yl)thiophene-2-sulfonyl chloride; 2-Thiophenesulfonyl chloride, 5-(2H-tetrazol-5-yl)-; Tetrazolyl thiophenesulfonyl chloride; 5-(Tetrazolyl)thiophene-2-sulfonyl chloride; 2-Sulfonylchloride-5-tetrazolylthiophene
EINECS	Contact for details

Quality Control

Our 2-Thiophenesulfonyl Chloride, 5-(2H-Tetrazol-5-Yl)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and industrial synthesis. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.