Description

3-(2-[4-(tert-Butoxycarbonyl)Piperazino]Ethoxy)-2-Thiophenecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. Its core value lies in its role as a key building block for the synthesis of complex molecules, particularly in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology industries, where it is used to develop new active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities in drug discovery programs.
• API Synthesis: Used in the production route for Active Pharmaceutical Ingredients (APIs) that incorporate a piperazine-thiophene pharmacophore.
• Bioconjugation & Probe Development: The carboxylic acid and protected piperazine functionalities make it suitable for creating labeled compounds or molecular probes for biochemical assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	3-(2-[4-(tert-Butoxycarbonyl)Piperazino]Ethoxy)-2-Thiophenecarboxylic Acid
CAS No.	924869-16-9
Molecular Formula	C16H24N2O5S
Molecular Weight	356.44 g/mol
Synonyms	Boc-Pip-Thiophene-COOH; 2-Thiophenecarboxylic acid, 3-[2-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]ethoxy]-; 3-[2-[4-(tert-Butoxycarbonyl)piperazin-1-yl]ethoxy]thiophene-2-carboxylic acid; tert-Butyl 4-[2-(2-carboxythiophen-3-yl)oxyethyl]piperazine-1-carboxylate; 924869-16-9; 3-(2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)ethoxy)thiophene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 3-(2-[4-(tert-Butoxycarbonyl)Piperazino]Ethoxy)-2-Thiophenecarboxylic Acid adheres to stringent quality management systems, ensuring batch-to-batch consistency suitable for research and cGMP manufacturing. Identity, purity, and impurity profiles are verified using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.