Description

3-Bromo-2-Trifluoromethylthiophene is a high-purity, multi-functional heterocyclic building block essential for advanced chemical synthesis. This compound is valued for its unique reactivity profile, enabling the introduction of both bromine and trifluoromethyl substituents onto a thiophene scaffold in a single, strategically positioned molecule. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecules with tailored electronic and physical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Organic Electronic Materials: Serves as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), field-effect transistors (OFETs), and photovoltaic cells.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis, facilitating challenging cross-coupling and functionalization reactions.
• Fluorinated Liquid Crystal Research: Acts as a core component in the design of fluorinated mesogens for advanced display technologies.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs serving the life sciences sector.

Basic Information

Product Name	3-Bromo-2-Trifluoromethylthiophene
CAS No.	924818-17-7
Molecular Formula	C5H2BrF3S
Molecular Weight	230.03 g/mol
Synonyms	2-Trifluoromethyl-3-bromothiophene; 3-Bromo-2-(trifluoromethyl)thiophene; Thiophene, 3-bromo-2-(trifluoromethyl)-; 3-Bromo-α,α,α-trifluoro-2-thiophenemethanol (related); Bromo(trifluoromethyl)thiophene
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Trifluoromethylthiophene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.