Description

2(1H)-Isoquinolinecarboxylic Acid, 1-[(4-Aminophenyl)Methyl]-6,7-Bis[(Ethoxycarbonyl)Oxy]-3,4-Dihydro-, 9H-Fluoren-9-Ylmethyl Ester is a complex, multifunctional organic compound designed for advanced chemical synthesis. This molecule is of significant interest for its role as a key synthetic intermediate or a protected precursor in the development of active pharmaceutical ingredients (APIs) and specialty fine chemicals. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and advanced material sectors, where precise molecular architecture is critical.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Prodrug Development: The bis(ethoxycarbonyl)oxy and fluorenylmethyl ester protecting groups make it a valuable precursor for designing prodrugs with enhanced bioavailability and targeted release profiles.
• Chemical Biology Research: Used as a scaffold or probe in medicinal chemistry for structure-activity relationship (SAR) studies and biological target identification.
• Advanced Material Synthesis: Potential monomer or cross-linking agent for creating specialized polymers with unique optical or electronic properties.
• Agrochemical Research: Employed in the synthesis of experimental plant protection agents and growth regulators.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	2(1H)-Isoquinolinecarboxylic Acid, 1-[(4-Aminophenyl)Methyl]-6,7-Bis[(Ethoxycarbonyl)Oxy]-3,4-Dihydro-, 9H-Fluoren-9-Ylmethyl Ester
CAS No.	924651-73-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-[(4-Aminobenzyl)]-6,7-bis(ethoxycarbonyloxy)-3,4-dihydro-2(1H)-isoquinolinecarboxylic acid 9H-fluoren-9-ylmethyl ester; 9H-Fluoren-9-ylmethyl 1-[(4-aminophenyl)methyl]-6,7-bis[(ethoxycarbonyl)oxy]-3,4-dihydro-2(1H)-isoquinolinecarboxylate; Fmoc-protected isoquinoline derivative; Bis-carbonate protected isoquinoline intermediate; CAS 924651-73-0
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems to ensure consistency and purity for sensitive synthetic applications. Our rigorous analytical protocols include HPLC, NMR, and mass spectrometry for identity confirmation and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider storing under an inert gas such as argon or nitrogen in a sealed container. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.