Description

Isoquinoline, 5,8-Difluoro-1,2,3,4- Tetrahydro- is a high-value, fluorinated tetrahydroisoquinoline derivative, serving as a critical pharmaceutical intermediate and advanced building block in organic synthesis. Its unique structure, featuring a saturated ring system with strategic fluorine substitutions, makes it indispensable for medicinal chemistry research and the development of novel active compounds. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets and enzyme inhibitors.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and library synthesis due to its fluorinated tetrahydroisoquinoline core.
• Agrochemical Development: Serves as a building block for novel herbicides, fungicides, or pesticides, leveraging the bioactivity-enhancing properties of fluorine atoms.
• Ligand Synthesis: Utilized in the preparation of specialized ligands for catalysis or metal-organic frameworks (MOFs).
• Fluorinated Compound Library: An important component in the creation of screening libraries for drug discovery programs focused on fluorinated molecules.
• Chemical Research: Employed in academic and industrial labs for methodological studies in heterocyclic and fluorination chemistry.

Basic Information

Product Name	Isoquinoline, 5,8-Difluoro-1,2,3,4- Tetrahydro-
CAS No.	924307-79-9
Molecular Formula	C9H7F2N
Molecular Weight	167.16 g/mol
Synonyms	5,8-Difluoro-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-5,8-difluoro-isoquinoline; 5,8-Difluoro-1,2,3,4-tetrahydroisoquinoline; 5,8-Difluorotetrahydroisoquinoline; 5,8-Difluoro-THIQ; 5,8-F2-THIQ; 5,8-Difluoro-3,4-dihydro-1H-isoquinoline
EINECS	Contact for details

Quality Control

Our 5,8-Difluoro-1,2,3,4-tetrahydroisoquinoline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization and purity verification. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). For long-term storage, consider keeping the material under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.