Description

4-Fluoro-Isoindoline Hydrochloride is a high-purity fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and agrochemicals, where the introduction of a fluorine atom can dramatically alter biological activity and metabolic stability. It is primarily needed by research institutions and industrial R&D departments focused on medicinal chemistry, particularly in the synthesis of complex heterocyclic compounds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the fluorine moiety enhances efficacy and environmental persistence.
• Material Science: Serves as a precursor for specialty polymers and advanced organic materials with tailored electronic properties.
• Chemical Synthesis: Employed in organic chemistry research for constructing complex isoindoline-based scaffolds and fluorinated heterocycles.
• Ligand & Catalyst Development: Utilized in the creation of novel ligands for catalysis and molecular recognition applications.
• Academic & Contract Research: Essential for fundamental research in universities and contract research organizations (CROs) exploring fluorination chemistry.

Basic Information

Product Name	4-Fluoro-Isoindoline Hydrochloride
CAS No.	924305-06-6
Molecular Formula	C8H9ClFN
Molecular Weight	173.61 g/mol
Synonyms	4-Fluoro-2,3-dihydro-1H-isoindole hydrochloride; 4-Fluoroisoindoline HCl; 1H-Isoindole, 4-fluoro-2,3-dihydro-, hydrochloride; 4-Fluoro-isoindoline hydrochloride; 4-Fluoro-2,3-dihydroisoindole hydrochloride; 4-Fluoro-1H-isoindoline hydrochloride; 4-Fluoroisoindoline Hydrochloride Salt
EINECS	Contact for details

Quality Control

Our 4-Fluoro-Isoindoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.