Description

[2H6]-Esomeprazole CAS NO 922800-06-4 is a stable isotope-labeled analog of the proton pump inhibitor esomeprazole, where six hydrogen atoms are replaced by deuterium. This compound is an essential internal standard for the precise quantification of esomeprazole in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism research.

Application

• Internal Standard for Bioanalysis: Serves as a critical reference compound for the accurate and sensitive quantification of esomeprazole in plasma, serum, and other biological samples via mass spectrometry.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Impurity Profiling: Used as a reference marker in the development and validation of analytical methods to identify and quantify related substances.
• Clinical Trial Support: Essential for ensuring data integrity in bioanalytical assays conducted during clinical trials for generic and innovator drug formulations.
• Forensic & Doping Control Analysis: Applied in specialized testing environments for the definitive identification and measurement of esomeprazole and its metabolites.

Basic Information

Product Name	[2H6]-Esomeprazole
CAS No.	922800-06-4
Molecular Formula	C17H13D6N3O3S
Molecular Weight	345.44 g/mol
Synonyms	Deuterated Esomeprazole; Esomeprazole-d6; (S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-d6; (S)-Omeprazole-d6; Perdex6 Esomeprazole; Nexium-d6; Isotopically Labeled Esomeprazole; Esomeprazole Internal Standard
EINECS	Contact for details

Quality Control

Every batch of [2H6]-Esomeprazole is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98%), and isotopic enrichment (typically ≥99 atom % D). Our quality commitment aligns with the standards expected for pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % D
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.