Description

5-(Trideuteriomethoxy)-1,3-Dihydrobenzimidazole-2-Thione is a deuterated derivative of the benzimidazole-2-thione scaffold, a key heterocyclic structure in medicinal chemistry. This compound is specifically designed for use as a stable isotope-labeled internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in pharmacokinetic and metabolic studies. It is an essential analytical tool for pharmaceutical researchers, contract research organizations (CROs), and diagnostic developers working on drug discovery and development programs.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS methods for the precise quantification of parent drugs and metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic (PK) Studies: Enables accurate determination of key PK parameters such as AUC, Cmax, and half-life by correcting for matrix effects and instrument variability.
• Metabolite Identification & Profiling: Used in stable isotope tracing experiments to study metabolic pathways and identify novel drug metabolites.
• Doping Control & Forensic Analysis: Provides a reliable reference standard for the confirmatory analysis of prohibited substances or specific biomarkers in forensic and anti-doping laboratories.
• Method Development & Validation: Essential for developing and validating robust, GLP/GCP-compliant analytical methods in regulated bioanalytical laboratories.

Basic Information

Product Name	5-(Trideuteriomethoxy)-1,3-Dihydrobenzimidazole-2-Thione
CAS No.	922730-86-7
Molecular Formula	C8H6D3N2OS
Molecular Weight	182.23 g/mol
Synonyms	5-(Trideuteromethoxy)-1H-benzimidazole-2-thiol; 5-(Methoxy-d3)-1,3-dihydro-2H-benzimidazole-2-thione; 2-Mercapto-5-(trideuteriomethoxy)benzimidazole; Deuterated Benzimidazolethione; 922730-86-7; 5-(CD3O)-Benzimidazole-2-thione; Internal Standard for LC-MS; Stable Isotope Labeled Benzimidazole
EINECS	Contact for details

Quality Control

Every batch of 5-(Trideuteriomethoxy)-1,3-Dihydrobenzimidazole-2-Thione is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC, NMR, and mass spectrometry to confirm structure, purity, and deuterium incorporation. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.