Description

Pantoprazole-D3 is a deuterium-labeled analog of the proton pump inhibitor pantoprazole, specifically designed for use as an internal standard in quantitative analytical methods. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses, particularly in pharmacokinetic and bioequivalence studies. It is a critical tool for pharmaceutical research and development laboratories, contract research organizations (CROs), and regulatory testing facilities that require precise measurement of pantoprazole in complex biological matrices.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of pantoprazole.
• Essential for bioanalytical method development and validation in clinical and preclinical studies.
• Used in pharmacokinetic (PK) and pharmacodynamic (PD) research to track drug absorption, distribution, metabolism, and excretion.
• Critical for conducting bioequivalence studies for generic drug applications submitted to regulatory bodies like the FDA and EMA.
• Supports drug metabolism and stability studies by providing a non-interfering reference signal.
• Applied in forensic and anti-doping analysis for the precise detection of pantoprazole.

Basic Information

Product Name	Pantoprazole-D3
CAS No.	922727-37-5
Molecular Formula	C16H12D3F2N3O4S
Molecular Weight	386.39 g/mol (for C16H12D3F2N3O4S)
Synonyms	Pantoprazole (methyl-d3); 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl](methyl-d3)sulfinyl]-1H-benzimidazole; 6-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl](methyl-d3)sulfinyl]-1H-benzimidazole; Pantoprazole-d3 (methyl-d3); Protonix-d3; Pantozol-d3; SKF-96022-d3; BY1023-d3
EINECS	Contact for details

Quality Control

Our Pantoprazole-D3 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, which are paramount for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment, and chromatographic profile. We adhere to relevant industry guidelines to support GMP and GLP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium content)	≥ 99.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.