Description

Acetylsalicylic Acid-D3 (CAS NO 921943-73-9) is a stable isotope-labeled analog of acetylsalicylic acid (aspirin), where three hydrogen atoms are replaced by deuterium. This compound is essential as an internal standard in quantitative analytical methods, providing unmatched accuracy and reliability for mass spectrometry-based assays. It is a critical material for pharmaceutical research, clinical laboratories, and forensic toxicology studies requiring precise measurement of aspirin and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for pharmacokinetic and bioanalytical studies.
• Pharmaceutical R&D: Enables precise tracking of drug metabolism, absorption, and excretion in deuterium-labeled tracer studies.
• Clinical Diagnostics: Used in assays to monitor aspirin levels and salicylate exposure in patient blood and plasma samples.
• Forensic Analysis: Supports accurate identification and quantification of acetylsalicylic acid in complex biological matrices.
• Method Development & Validation: Critical for developing, calibrating, and validating new analytical methods in compliance with GLP and ISO 17025 standards.
• Metabolomics Research: Facilitates pathway analysis and metabolic flux studies in biochemical and pharmacological research.

Basic Information

Product Name	Acetylsalicylic Acid-D3
CAS No.	921943-73-9
Molecular Formula	C9H5D3O4
Molecular Weight	183.16 g/mol
Synonyms	2-(Acetyloxy)benzoic-3,4,5-d3 acid; Aspirin-d3; Deuterated Aspirin; Acetylsalicylic Acid (phenyl-d3); ASA-d3; o-Acetoxybenzoic Acid-d3; 2-Acetoxybenzoic Acid-d3; Benzoic acid, 2-(acetyloxy)-, phenyl-d3
EINECS	Contact for details

Quality Control

Our Acetylsalicylic Acid-D3 is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (by NMR or MS), and residual solvent content. We adhere to relevant standards for reference materials, and custom purity grades are available to meet specific research or diagnostic requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.